Kuopio: Prodrug technology and Continuous processing workshops & Meeting with FinPharmaNet for graduate students

Programme:

08:00 - 08:15 Opening of the workshop / Assoc. Prof. Teijo Saari, Department of Anesthesiology and Intensive Care, University of Turku, Finland & Prof. Jarkko Rautio, School of Pharmacy, University of Eastern Finland, Finland

08:15 - 09:00 Keynote lecture: Design and clinical evaluation of the hypoxia-activated prodrug PR-104 / Prof. William A. Denny, Auckland Cancer Society Research Center, University of Auckland, New Zealand

09:00 - 09:45 Keynote lecture: Multifunctional drugs assembled by oligonucleotides / Prof. Kurt Vesterager Gothelf, Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Denmark

09:45 - 10:00 Coffee break

10:00 - 10:15 Introduction to prodrugs / Adj. Prof. Kristiina M. Huttunen, School of Pharmacy, University of Eastern Finland, Finland

10:15 - 11:00 Targeting by prodrugs - enzyme-prodrug strategies/ Assoc. Prof. Alexander Zelikin, Department of Chemistry, Aarhus University, Denmark

11:00 - 11:45 Focal chemotherapy under bioorthogonal control/ Prof. Asier Unciti-Broceta, Cancer Research UK Edinburgh Centre, University of Edinburgh, UK

11:45 - 12:30 Lunch break

12:30 - 13:15 Transporter-utilizing prodrugs in brain-targeting/ Adj. Prof. Kristiina M. Huttunen, School of Pharmacy, University of Eastern Finland, Finland

13:15 - 13:30 Introduction to bioconjugates/ Dr. Astrid Subrizi, School of Pharmacy, University of Eastern Finland, Finland

13:30 - 14:15 Molecular engineering of bioconjugates / Dr. Tessa Lühmann, Institute for Pharmacy and Food Chemistry, University of Wurzburg, Germany

14:15 - 14:30 Coffee break

14:30 - 15:15 Targeting subcellular trafficking to generate antibody-based therapeutics / Prof. E. Sally Ward, Centre for Cancer Immunology, University of Southampton, UK

Topics:

The webinar topics cover findings and solutions to overcome pitfalls and hurdles in implementing Continuous Processing ranging from

• continuous crystallization,
• modelling and
• PAT to material and formulation properties

Organizers:

The webinar is organized by School of Pharmacy / Promis Lab, University of Eastern Finland, hosting one of the few full continuous tablet manufacturing lines in Europe, in collaboration with FinPharmaNet (Finnish Graduate School Network in Pharmaceutical Research) and PARC (Pharmaceutical Applied Research Center), Czech Republic.

Programme

09:15 - 10:00 Keynote lecture: Postgraduate studies and industrial collaboration: The Parc (Pharmaceutical Applied Research Center)/ Prof. František Štěpánek, University of Chemistry and Technology Prague, Czech Republic

10:00 - 10:15 Opening of the workshop / Prof. Jarkko Ketolainen, School of Pharmacy, University of Eastern Finland, Finland

10:15 - 10:45 Continuous tablet manufacturing – State of Art / Prof. Ossi Korhonen, School of Pharmacy, University of Eastern Finland, Finland

10:45 - 11:15 UEF PromisLab – Virtual lab tour / Dr. Tuomas Ervasti, School of Pharmacy, University of Eastern Finland, Finland

11:15 - 11:45 Challenges and opportunities for real-time release testing in continuous tablet manufacturing / Dr. Daniel Markl, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, UK

11:45 - 12:30 Lunch break

12:30 - 13:00 Developing a continuous drug substance manufacturing process / Dr. Cameron Brown, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, UK

13:00 - 13:30 Computational tools in process design / Dr. Luis Martin de Juan, Astra Zeneca, Sweden

13:30 - 13:45 Coffee break

13:45 - 14:15 Company drivers towards continuous manufacturing – A generic company’s view / Dr. Pawel Stasiak, Zentiva, Czech Republic

14:15 – 14:45 Tackling the challenge of critical material attributes in continuous wet granulation / Dr. Fanny Stauffer, UCB, Belgium

14:45 - 15:15 Process simulation and validation of continuous tableting / Dr. Anssi-Pekka Karttunen, Nanoform, Finland