Physiologically based pharmacokinetic modeling (PBPK) course
The aim is to give an overview of physiologically based pharmacokinetic modeling (PBPK). The lectures cover both the basic theory and several applications, including inter-species scaling from animals to human, modeling of drug-drug interactions, and pharmacokinetics in special patient groups. In addition, hands-on calculation sessions with PK Sim software (freeware) are included.
Principal Teachers
Professor Leon Aarons, University of Manchester
Language: English
Lecturers and instructors in the hands-on sessions
Professor Leon Aarons, University of Manchester, United Kingdom
Assistant professor Adam Darwich, KTH Royal Institute of Technology, Sweden
Lecturer Veli-Pekka Ranta, University of Eastern Finland
Ph.D. Eva del Amo, University of Eastern Finland
Preliminary program
October 11th, 2022
9.00-10.15 Registration
10.00-10.45 Introduction to PBPK modeling
Leon Aarons
10.45-11.00 Break
11.00-12.00 PBPK theory: Perfusion- and permeability-limited drug distribution
Leon Aarons
12.00-13.00 Lunch
13.00-14.15 PBPK theory: Hepatic and renal elimination, and Compilation of a whole-body PBPK model for intravenous administration
Leon Aarons
14.15-14.30 Break
14.30-18.00 Hands-on 1 with PK sim: first models for intravenous and per oral administrations.
Leon Aarons, Adam Darwich, Eva del Amo, and Veli-Pekka Ranta
19-21 Evening dinner: Hotel Scandic Atlas (Haapaniemenkatu 22)
October 12th, 2022
8.30-9.40 PBPK theory: Defining dissolution and absorption from the gut for per oral administration
Adam Darwich
9.40-10.00 Break
10.00-11.00 PBPK theory: metabolic drug-drug interactions
Adam Darwich
11.00-12.00 Lunch
12.00-14.30 Hands-on 2 with PK Sim: example of metabolic drug-drug interaction
Leon Aarons, Adam Darwich, Eva del Amo, and Veli-Pekka Ranta
14.30-16.00 Applications of PBPK:
Dr. Anne Filppula (Åbo Akademi University, Turku, Finland): PBPK modelling as a tool to elucidate clinical drug-drug interactions
Dr. Timo Korjamo (Orion Pharma, Espoo, Finland): Absorption predictions using PBPK modelling
Dr. Aki Heikkinen (Admescope, Oulu, Finland): First-in-human PK predictions
16.00-16.10 Closing the course
Leon Aarons, Adam Darwich, Eva del Amo, and Veli-Pekka Ranta
The course is intended for post-graduate students and senior scientists in pharmacy, drug discovery & development, clinical research, and toxicology in Finland and abroad.
The course includes coffee/tea breaks, lunches, and the buffet dinner:
- • Free (all-inclusive) for NordicPOP academic partners* (up to 40 participants)
- • Course fee of 150 € (VAT included) for other academic participants.
- • Course fee of 300 € (VAT included) for industry and regulatory agencies participants.
Undergraduate students with adequate training in pharmacokinetics may also attend the course, but unfortunately, we cannot provide catering, lunches, and buffet dinner for them. Accommodation is not provided by the course organizers, but a special price is available in Hotel Scandic Atlas (see below).
Hotel Scandic Atlas is located conveniently beside the marketplace and it offers special prices for the participants on October 10-13, 2022:
a single room 104 €/night, and a double room 124 €/night including organic breakfast and WIFI.
The reservation code is BSCH101022, and the reservation can be made through the following link:
www.scandichotels.fi?bookingcode=BSCH101022 , or website or by contacting the hotel directly via telephone (+358300 8704 23) / email (atlas@scandichotels.com) using the cited booking code. Reservations can be made until 26.9.2022 or subject to hotel availability.
Financial support
Nordic POP consortium is supported by NordForsk program Nordic University Hub (project #85352)
via School of Pharmacy, University of Eastern Finland.
Faculty of Health Sciences, University of Eastern Finland.
The doctoral programme in Drug Research, University of Helsinki.
The course is equivalent to 1.0 ECTS-credit points for the 2-day course, or a total of 2.0 ECTS-credit points when the participant solves voluntary pre-and post-course modeling exercises. Each participant is expected to bring a personal laptop and install PK Sim software (only available in Windows) before the course. However, it is possible to work as a pair. Course material and instructions for software installation will be emailed to the participants two weeks before the course.
Registration
Registration for the course is made via web page:
https://forms.office.com/r/xu6V5prbyk
Nordic POP consortium is supported by NordForsk program Nordic University Hub (project #85352)
via School of Pharmacy, University of Eastern Finland.
Faculty of Health Sciences, University of Eastern Finland.
The doctoral programme in Drug Research, University of Helsinki.
Credits, course material, and software
The course is equivalent to 1.0 ECTS-credit points for the 2-day course, or a total of 2.0 ECTS-credit points when the participant solves voluntary pre-and post-course modeling exercises.
Each participant is expected to bring a personal laptop and install PK Sim software (only available in Windows) before the course. However, it is possible to work as a pair.
Course material and instructions for software installation will be emailed to the participants two weeks before the course.