Articles in peer-reviewed journals

 

  • Rantanen J, Fatouros DG. (2021). Preface: Additive manufacturing in pharmaceutical product design.. Adv. Drug Del. Rev  113991
  • Chao M, Öblom H, Cornett C, Bøtker J, Rantanen J, Sporrong S, Genina N. (2021). Data-Enriched Edible Pharmaceuticals (DEEP) with Bespoke Design, Dose and Drug Release. Pharmaceutics,
  • Palmelund H, Eriksen JB, Bauer-Brandl A, Rantanen J, Löbmann K. (2021). Enabling formulations of aprepitant: in vitro and in vivo comparison of nanocrystalline, amorphous and deep eutectic solvent based formulations.. International journal of pharmaceutics: X, pp. 100083
  • Raijada D, Wac K, Greisen E, Rantanen J, Genina N. (2021). Integration of personalized drug delivery systems into digital health.. Adv. Drug Del. Rev , 113857
  • Eleftheriadis G., Genina N, Botker J, Rantanen J, 2021. Modular design principle based on compartmental drug delivery systems. Adv. Drug Del. Rev 113921
  • Herzberg M, Zeng G, Mäkilä E, Murtomaa M, Søgaard S, Garnæs J, Madsen A... Rantanen J. (2021). Effect of dehydration pathway on the surface properties of molecular crystals. CrystEngComm, 23 2933-2937
  • K Be̅rziņš, SJ Fraser-Miller, R Di, J Liu, L Peltonen, CJ Strachan et col. Combined Effect of the Preparation Method and Compression on the Physical Stability and Dissolution Behavior of Melt-Quenched Amorphous Celecoxib. Mol. Pharmaceutics 2021, 18, 3, 1408–1418
  • M Falavigna, M Klitgaard, R Berthelsen, A Müllertz, GE Flaten. Predicting oral absorption of fenofibrate in lipid-based drug delivery systems by combining in vitro lipolysis with the mucus-PVPA permeability model. Journal of pharmaceutical sciences 110 (1), 208-216.
  • D Dahlgren, M Venczel, JP Ridoux, C Skjöld, A Müllertz, R Holm. 2021. Fasted and fed state human duodenal fluids: Characterization, drug solubility, and comparison to simulated fluids and with human bioavailability. European journal of pharmaceutics and biopharmaceutics 163, 240-251
  • Z Vinarov, B Abrahamsson, P Artursson, H Batchelor, P Berben. 2021. Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network. Advanced Drug Delivery Reviews
  • C Heerup, MF Ebbesen, X Geng, SF Madsen, R Berthelsen, A Müllertz. Effects of recombinant human gastric lipase and pancreatin during in vitro pediatric gastro-intestinal digestion. Food & Function 12 (7), 2938-2949
  • M Chao, H Öblom, C Cornett, J Bøtker, J Rantanen, SK Sporrong. 2021. Data-Enriched Edible Pharmaceuticals (DEEP) with Bespoke Design, Dose and Drug Release. Pharmaceutics 13 (11), 1866
  • GK Eleftheriadis, N Genina, J Boetker, J Rantanen. Modular design principle based on compartmental drug delivery systems. Advanced Drug Delivery Reviews 178, 113921
  • Frederik A. Hansen, Nickolaj J. Petersen, Jörg P. Kutter, Stig Pedersen-Bjergaard.2021. Electromembrane extraction in microfluidic formats. Journal of Separation Science 2022, 45, 246-257 (first published: Sep 25, 2021)
  • Frøydis S. Skottvoll, Aleksandra Aizenshtadt, Frederik A. Hansen, Mikel A. Martinez, Jannike M. Andersen, Inger L. Bogen, Jörg P. Kutter, Stig Pedersen-Bjergaard, Elsa Lundanes,  Stefan J. K. Krauss, Steven R. H. Wilson. Direct electromembrane extraction based mass spectrometry: A tool for studying drug metabolism properties of liver organoids. Analysis & Sensing, https://doi.org/10.1002/anse.202100051 (first published Dec 21, 2021)
  • Hempel NJ, Merkl P, Asad S, Knopp MM, Berthelsen R, Bergström C, Teleki A, Sotiriou G, Löbmann K. Utilizing laser-activation of photothermal plasmonic nanoparticles to induce on-demand drug amorphization inside a tablet. Molecular Pharmaceutics 2021, 12, 2254-2262. This also made it to a cover page on MolPharm
  • Hempel NJ, Merkl P, Knopp MM, Berthelsen R, Teleki A, Sotiriou G, Löbmann K. The influence of the drug-polymer solubility on laser-induced in situ drug amorphization using photothermal plasmonic nanoparticles. Pharmaceutics2021, 13, 917.
  • Zhen Wang, Yichuan Wang, Jiaqi Yan, Keshi Zhang, Feng Lin, Lei Xiang, Lianfu Deng, Zhenpeng Guan, Wenguo Cui, Hongbo Zhang, "Pharmaceutical Electrospinning and 3D printing scaffold design for bone regeneration", Adv. Drug. Deliv. Rev. 2021., 174, 504-534
  • Feng Zhang, Yiran Zhang, Li Kong, Huanhuan Luo, Yuezhou Zhang, Ermei Mäkilä, Jarno Salonen, Jouni T. Hirvonen, Yueqi Zhu, Yingsheng Cheng, Lianfu Deng, Hongbo Zhang*, Alexander Kros, Wenguo Cui*, Hélder A. Santos*, “Multistage Signal Interactive Nanoparticles Improves Tumor Targeting Through Efficient Nanoparticle-Cell Communications”, Cell Rep. 2021, 35,  109131
  • Huanhuan Luo, Li Kong, Feng Zhang, Chenglong Huang, Jiayi Chen, Hongbo Zhang, Han Yu, Song Zheng, Hongwei Xu, Yiran Zhang, Lianfu Deng, Gang Chen*, Hélder A. Santos*, Wenguo Cui*, “Light-Controlled Nanosystem With Size Flexibility Improves Targeted Retention for Tumor Suppression”, Adv. Funct. Mater. 2021.
  • Lu Chen, Liucheng Zhang, Hongbo Zhang, Xiaoming Sun, Dan Liu, Jianming Zhang, Yuguang Zhang*, Liying Cheng*, Hélder A. Santos*, Wenguo Cui*, “Programmable Immune Activating Electrospun Fibers for Skin Regeneration”, Bioact. Mater. 2021, 6 (10), 3218-3230
  • Zhijie Chen, Feng Zhang, Hongbo Zhang, Liang Cheng, Kaizhe Chen, Jieliang Shen, Jin Qi, Lianfu Deng, Chuan He*, Hélder A. Santos*, Wenguo Cui*, “DNA-Grafted Hyaluronic Acid System with Enhanced Injectability and Biostability for Photo-Controlled Osteoarthritis Gene Therapy”, Adv. Sci. 2021.
  • Xu Zhang*, Hongbo Zhang, Jianmei Gu, Jiayin Zhang, Hui Shi, Hui Qian, Dongqing Wang, Wenrong Xu, Jianming Pan*, Hélder A. Santos*, “Engineered Extracellular Vesicles for Cancer Therapy”, Adv. Mater. 2021, 33(14) e2005709.
  • Qiaolin Wei, Hamed Arami,, Hélder A. Santos, Hongbo Zhang, Yangyang Li,, Jian He, Danni Zhong, Daishun Ling, Min Zhou. "Intraoperative Assessment and Photothermal Ablation of the Tumor Margins Using Gold Nanoparticles", Adv. Sci. 2021, 8(5), 2002788.
  • O. Kissi, R. Nilsson, L.P. Nogueira, A. Larsson, I. Tho (2021) Influence of Drug Load on the Printability and Solid-State Properties of 3D-Printed Naproxen-Based Amorphous Solid Dispersion. Molecules 2021, 26(15), 4492
  • Govender, E.O.Kissi, A.Larsssen, I.Tho (2021) Polymers in pharmaceutical additive manufacturing: A balancing act between printability and product performance. Advanced Drug Delivery Reviews 177, 13923,
  • Tzanova, E.Randeliv, P.Stein, M.Hiorth, M.P di Cagno (2021) Towards a better mechanistic comprehension of drug permeation and absorption: Introducing the diffusion-partitioning interplay. Int. J Pharm 608, 121116
  • E Koivunotko, A Merivaara, A Niemelä, S Valkonen, K Manninen, H Mäkinen, M Viljanen, K Svedström, A Diaz, M Holler, J Zini, L Paasonen, O Korhonen, S Huotari, A Koivuniemi, M Yliperttula. Molecular Insights on Successful Reconstitution of Freeze-Dried Nanofibrillated Cellulose Hydrogel. ACS Appl. Bio. Mater. 4(9), 7157-7167, (2021)
  • A Merivaara, J Zini, E Koivunotko, S Valkonen, O Korhonen, FM Fernandes, M Yliperttula. Preservation of Biomaterials and Cells by Freeze-Drying: Change of Paradigm. J. Control. Rel. 336(10), 480-498, (2021)
  • T Pedersen, A-P Karttunen, O Korhonen, J Xiong Wu, K Naelapää, E Skibsted, J Rantanen. Determination of residence time distribution in a continuous powder mixer using in-line near infrared (NIR) spectroscopy. J.Pharm.Sci. 110(3): 1259-1269, (2021)
  • L Viidik, J Vesala, R Laitinen, O Korhonen, J Ketolainen, J Aruväli, K Kirsimäe, K Kogermann, J Heinämäki, I Laidmäe, T Ervasti. Preparation and characterization of hot-melt extruded polycaprolactone-based filaments intended for 3D-printing of tablets. Eur. J. Pharm. Sci. 158 (1), 2021
  • Germini, Peltonen, 2021. 3D Printing of Drug Nanocrystals for Film Formulations. Molecules, 26(13), 3941; https://doi.org/10.3390/molecules26133941

 

  • Figueiredo, A. Lepland, P. Scodeller et al., Peptide-guided resiquimod-loaded lignin nanoparticles convert tumor-associated macrophages from M2 to M1 phenotype for enhanced chemotherapy, Acta Biomaterialia, 

  •  Öblom, H., Cornett, C., Bøtker, J., Frokjaer, S., Hansen, H., Rades, T., Rantanen, J., Genina, N.,2020. Data-enriched edible pharmaceuticals (DEEP) of medical cannabis by inkjet printing. Int. J. Pharm. 589, 

 

  • Falavigna, M. Klitgaard, R. Berthelsen, A. Müllertz, G.E. Flaten (2020), Predicting oral absorption of fenofibrate in lipid-based drug delivery systems by combining in vitro lipolysis with the mucus-PVPA permeability model, JPharmSci,DOI:https://doi.org/10.1016/j.xphs.2020.08.026

 

 

 

 

 

 

  • Wang, JW; Gregoire, N; Marchand, S; Kutter, JP; Mu, HL; Moodley, A; Couet, W; Yang, MS, Improved antibacterial efficiency of inhaled thiamphenicol dry powders: Mathematical modelling of in vitro dissolution kinetic and in vitro antibacterial efficacy. 2020. Eur J Pharm Sci 152,doi 10.1016/j.ejps.2020.105435

 

  • Rajora, AK; Ravishankar, D; Zhang, HB; Rosenholm, JM, Recent Advances and Impact of Chemotherapeutic and Antiangiogenic Nanoformulations for Combination Cancer Therapy. 2020. Pharmaceutics 12(6), doi 10.3390/pharmaceutics12060592

 

 

 

 

  • Malekkhaiat-Häffner, L. Nyström, A. Strömstedt, L. Li, M.J.A. van der Plas, and M. Malmsten, Nanoclay-Induced Bacterial Flocculation for Infection Confinement. J. Colloid Interface Sci. 2020, 562, 71. (2020), https://doi.org/10.1021/acsami.9b03527

 

 

 

 

 

 

 

 

  • Bungert N, Kobler M, Scherließ R. (2022). The role of intrinsic fines in the performance change of expired lactose carriers for DPI applications. European Journal of Pharmaceutics and Biopharmaceutics, https://doi.org/10.1016/j.ejpb.2022.04.006
  • Bock, S, Rades, T, Rantanen, J & Scherließ, R (2022), 'Additive manufacturing in respiratory sciences – Current applications and future prospects', Advanced Drug Delivery Reviews, vol. 186, 114341. 10.1016/j.addr.2022.114341
  • Meiland, P, Larsen, BS, Knopp, MM, Tho, I & Rades, T( 2022), 'A new method to determine drug-polymer solubility through enthalpy of melting and mixing', International Journal of Pharmaceutics, vol. 629, 122391. https://doi.org/10.1016/j.ijpharm.2022.1223911
  • M Chao, N Genina, N Beer, SK Sporrong (2022). Data-enriched edible pharmaceuticals (DEEPs): Patients' preferences, perceptions, and acceptability of new dosage forms and their digital aspects–An interview study. Exploratory Research in Clinical and Social Pharmacy 6, 100141, https://doi.org/10.1016/j.rcsop.2022.100141
  • Stie, MB, Öblom, H, Hansen, CAN, Jacobsen, J, Chronakis, IS, Rantanen, J (2022). Mucoadhesive chitosan-and cellulose derivative-based nanofiber-on-foam-on-film system for non-invasive peptide delivery. Carbohydrate Polymers 303, 120429, https://doi.org/10.1016/j.carbpol.2022.120429
  • Li, Y, Li, M, Rantanen, J, Yang, M & Bohr, A 2022, 'Transformation of nanoparticles into compacts: A study on PLGA and celecoxib nanoparticles', International Journal of Pharmaceutics, vol. 611, 121278. https://doi.org/10.1016/j.ijpharm.2021.121278
  • Kabedev A, Zhuo X, Leng D, Foderà V, Zhao M, Larsson P, Bergström CAS... Löbmann K. (2022). Stabilizing Mechanisms of β-Lactoglobulin in Amorphous Solid Dispersions of Indomethacin.. Molecular pharmaceutics, 19 (11), pp. 3922-3933, 10.1021/acs.molpharmaceut.2c00397
  • Ansari SR, Hempel NJ, Asad S, Svedlindh P, Bergström CAS, Löbmann K, Teleki A. (2022). Hyperthermia-Induced In Situ Drug Amorphization by Superparamagnetic Nanoparticles in Oral Dosage Forms.. ACS applied materials & interfaces, 14 (19), pp. 21978-21988, 10.1021/acsami.2c03556
  • Eriksen JB, Barakat H, Luppi B, Brandl M, Bauer-Brandl A. (2022). Modulation of Paracellular-like Drug Transport across an Artificial Biomimetic Barrier by Osmotic Stress-Induced Liposome Shrinking.. Pharmaceutics, 14 (4), 10.3390/pharmaceutics14040721
  • Novakovic D, Peltonen L, Isomäki A, Fraser-Miller SJ, Nielsen LH, Laaksonen T, Strachan CJ. (2020). Surface Stabilization and Dissolution Rate Improvement of Amorphous Compacts with Thin Polymer Coatings: Can We Have It All?. Molecular pharmaceutics, 17 (4), pp. 1248-1260, 10.1021/acs.molpharmaceut.9b01263
  • Holsæter, K. Wizgird, I. Karlsen, J. F. Hemmingsen, M. Brandl, N. Skalko-Basnet (2022), How docetaxel entrapment, vesicle size, zeta potential and stability change with liposome composition–A formulation screening study. European Journal of Pharmaceutical Sciences. https://doi.org/10.1016/j.ejps.2022.106267
  • Corazza, E. Massimiliano Pio di Cagno, Bauer-Brandl, A., Abruzzo, A. Cerchiara, T. Bigucci, F., Luppi, B.  (2022) Drug delivery to the brain: In situ gelling formulation enhances carbamazepine diffusion through nasal mucosa models with mucin. https://doi.org/10.1016/j.ejps.2022.10
  • Martina M. Tzanova, Federica Moretti, Gabriele Grassi, Paul C. Stein, Marianne Hiorth, Michela Abrami, Mario Grassi, Massimiliano Pio di Cagno (2022) Modelling drug diffusion through unstirred water layers allows real-time quantification of free/loaded drug fractions and release kinetics from colloidal-based formulations, https://doi.org/10.1016/j.ejpb.2022.08.009
  • KE Kvitne, V Krogstad, Ch Wegler, LK Johnson, MK. Kringen, MH Hovd, JK. Hertel, M Heijer, RSandbu, ESkovlund, PArtursson, C Karlsson, Si Andersson, TB Andersson, J Hjelmesæth, A Åsberg, RJansson-Löfmark, H Christensen, I Robertsen (2022) Short- and long-term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity, https://doi.org/10.1111/bcp.15349
  • M Hytti, J Ruuth, I Kanerva, N Bhattarai, ML Pedersen, CU Nielsen, A Kauppinen (Epub 2022) Phloretin inhibits glucose transport and reduces inflammation in human retinal pigment epithelial cells, 10.1007/s11010-022-04504-2
  • J B Eriksen, JJ Christiansen, A Bauer-Brandl, M Ruponen, J Rautio, M Brandl: In-vitro dynamic dissolution/bioconversion/permeation of fosamprenavir using a novel tool with an artificial biomimetic permeation barrier and microdialysis-sampling. European Journal of Pharmaceutical Sciences 181(1), 106366, 2023, 10.1016/j.ejps.2022.106366
  • A Merivaara, J Kekkonen, J Monola, E Koivunotko, M Savolainen, T Silvast, K Svedström, A Diaz, MHoller, O Korhonen, M Yliperttula, SValkonen. Near-infrared analysis of nanofibrillated cellulose aerogel manufacturing, https://doi.org/10.1016/j.ijpharm.2022.121581
  • S Tavakoli; J Puranen; S Bahrpeyma; VE. Lautala; S Karumo; TE Anton Lajunen; EM. del Amo; M Ruponen; A Urtti, https://doi.org/10.1016/j.ijpharm.2022.
  • ASadeghi; M Ruponen; JPuranen; S Cao; R Ridolfo; STavakoli; E Toropainen; TE Anton Lajunen; Veli-Pekka Ranta; J van Hest et al. 121https://doi.org/10.1016/j.ijpharm.2022.121800
  • Vili-Veli A Auvinen; P Laurén; B Shen; J Isokuortti; N Durandin; T Lajunen; VLinko; T Laaksonen, https://doi.org/10.1007/s10570-022-04875-1
  • MSBohsen, ST Tychsen, AAH Kadhim, H Grohganz, AH. Treusch, M Brandl, Interaction of liposomes with bile salts investigated by asymmetric flow field-flow fractionation (AF4): A novel approach for stability assessment of oral drug carriers,European Journal of Pharmaceutical Sciences,Volume 182,accepted 2022, pblshd 2023,106384,ISSN 0928-0987, https://doi.org/10.1016/j.ejps.2023.106384., https://doi.org/10.1016/j.ejps.2023.106384
  • JB Eriksen, JJ Christiansen, ABauer-Brandl, M Ruponen, J Rautio, M Brandl, In-vitro dynamic dissolution/bioconversion/permeation of fosamprenavir using a novel tool with an artificial biomimetic permeation barrier and microdialysis-sampling, European Journal of Pharmaceutical Sciences, Volume 181, submitted 2022, published 2023,106366, ISSN 0928-0987,https://doi.org/10.1016/j.ejps.2022.106366.
  • Am Holsæter, K Wizgird, IKarlsen, JF Hemmingsen, M Brandl, N Škalko-Basnet, How docetaxel entrapment, vesicle size, zeta potential and stability change with liposome composition–A formulation screening study, European Journal of Pharmaceutical Sciences, Volume 177,2022,106267,ISSN 0928-0987,https://doi.org/10.1016/j.ejps.2022.106267.               
  • JT Lynnerup, JB Eriksen, A Bauer-Brandl, AM Holsæter, M Brandl, Insight into the mechanism behind oral bioavailability-enhancement by nanosuspensions through combined dissolution/permeation studies,European Journal of Pharmaceutical Sciences,Volume 184, submitted 2022, published 2023, 106417,ISSN 0928-0987,https://doi.org/10.1016/j.ejps.2023.106417.
  • H Lösing, JB Eriksen, R Scherliess, A Bauer-Brandl, Inexpensive and Easy-To-Use Alternative to the Die Holder for Pharmacopoeial Intrinsic Dissolution Tests, submitted 2022, Open AccessPublished:February 28, 2023, pharmsci, DOI:https://doi.org/10.1016/j.xphs.2023.02.020
  • R Cheng, LJiang, HGao, ZLiu, E Mäkilä, S Wang, Q Saiding, LXiang, X Tang, M Shi, JLiu, L Pang, J Salonen, J Hirvonen, HZhang, W Cui, B Shen, HA. Santos, "A pH-Responsive cluster metal-organic framework nanoparticle for enhanced tumor accumulation and antitumor effect", Advanced Materials, 2022, 2203915. 10.1002/adma.202270290
  • Xiaohui Mou, Hongbo Zhang, Hua Qiu, Wentai Zhang, Ying Wang, Kaiqin Xiong, Nan Huang, Hélder A. Santos, and Zhilu Yang, "Mussel-Inspired and Bioclickable Peptide Engineered Surface to Combat Thrombosis and Infection", Research, 2022, 9780879. 10.34133/2022/9780879
  • Zhang, CJ, H Zhang, H Shi, F Mao, H Qian, W Xu, DWang, Jianming, X Fang, HA. Santos, X Zhang, “Engineered Neutrophil-Derived Exosome-Like Vesicles for Targeted Cancer Therapy”, Adv. 2021, 8, eabj8207 , 10.1126/sciadv.abj8207
  • JV Tähtinen, VGulumkar, SK. Maity, A-M Yliperttula, SSiekkinen, T Laine,E Lisitsyna, I Haapalehto, T Viitala, EVuorimaa-Laukkanen, M Yliperttula,  P Virta, Assembly of Bleomycin Saccharide-Decorated Spherical Nucleic Acids. 10.1021/acs.bioconjchem.1c00539